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This is demonstrated by comparing the effects of DPP-4 inhibitors vs

Mieczkowska A, Irwin N, Flatt PR, Chappard D, Mabilleau G

The answer was no

2.3 Role of taste receptors in the gastrointestinal hormone secretion Although, we commonly associate TRCs and TASR only to the oral cavity, they are also localized in extra-oral tissues, including the gastrointestinal tract, where they participate in energy homeostasis by modulating enteroendocrine hormone release (GLP-1, GIP, CCK, PYY) and nutrient sensing, thereby influencing gastric emptying and metabolic adjustments (e.g., glycemia) (59, 60)

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Clinical evidence from the STEP trials demonstrated that higher doses produce greater weight loss, with the 2.4 mg dose resulting in approximately 15% body weight reduction over 68 weeks compared to placebo